Designing Multivalent Ligands to Control Biological Interactions: From Vaccines and Cellular Effectors to Targeted Drug Delivery,Chemistry - An Asian Journal

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Designing Multivalent Ligands to Control Biological Interactions: From Vaccines and Cellular Effectors to Targeted Drug Delivery
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2019-01-04 , DOI: 10.1002/asia.201801677
Ammar Arsiwala ₁ , Ana Castro ₁ , Steven Frey ₁ , Mark Stathos ₁ , Ravi S. Kane ₁

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Multivalent interactions in which multiple ligands on one object bind to multiple receptors on another are commonly found in natural biological systems. In addition, these interactions can lead to increased strength and selectivity when compared to the corresponding monovalent interaction. These attributes have also guided the design of synthetic multivalent ligands to control biological interactions. This review will highlight the recent literature describing the use of multivalent ligand display in the design of vaccines, immunomodulators, cell signaling effectors, and vehicles for targeted drug delivery.

中文翻译：

设计多价配体以控制生物相互作用：从疫苗和细胞效应子到靶向药物的输送

在天然生物系统中通常发现其中一个物体上的多个配体与另一个物体上的多个受体结合的多价相互作用。另外，与相应的单价相互作用相比，这些相互作用可导致强度和选择性的提高。这些属性也指导了合成多价配体的设计，以控制生物相互作用。这篇综述将着重介绍描述多价配体展示在疫苗，免疫调节剂，细胞信号传导效应器和靶向药物递送载体设计中的最新文献。

更新日期：2019-01-04

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