A circuit from hippocampal CA2 to lateral septum disinhibits social aggression,Nature

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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
Nature ( IF 50.5 ) Pub Date : 2018-12-01 , DOI: 10.1038/s41586-018-0772-0
Felix Leroy ₁ , Jung Park ₁ , Arun Asok ₁ , David H Brann ₁ , Torcato Meira _{1,

2,

3} , Lara M Boyle ₁ , Eric W Buss ₁ , Eric R Kandel _{1,

4} , Steven A Siegelbaum ₁

Affiliation

Although the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced immediately before an attack. Activation of the lateral septum by CA2 recruits a circuit that disinhibits a subnucleus of the ventromedial hypothalamus that is known to trigger attack. The social hormone arginine vasopressin enhances social aggression by acting on arginine vasopressin 1b receptors on CA2 presynaptic terminals in the lateral septum to facilitate excitatory synaptic transmission. In this manner, release of arginine vasopressin in the lateral septum, driven by an animal’s internal state, may serve as a modulatory control that determines whether CA2 activity leads to declarative memory of a social encounter and/or promotes motivated social aggression.Pyramidal neurons in the hippocampal CA2 region in mice promote social aggression via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.

中文翻译：

从海马 CA2 到侧隔的回路抑制社交攻击

虽然众所周知海马体对陈述性记忆很重要，但海马体输出如何调节动机行为（如社交攻击）尚不清楚。在这里，我们报告海马 CA2 区域的锥体神经元对社会记忆很重要，它促进了小鼠的社会攻击性。这个动作取决于从 CA2 到侧隔的输出，在攻击前有选择性地增强。CA2 对侧隔的激活募集了一个回路，该回路解除了已知会触发攻击的下丘脑腹内侧亚核的抑制。社会激素精氨酸加压素通过作用于侧隔中 CA2 突触前末端的精氨酸加压素 1b 受体来促进兴奋性突触传递，从而增强社会攻击性。以这种方式，

更新日期：2018-12-01

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