Excess bilirubin in blood can provoke hepatic damage and related malfunctions. Hereby we designed and constructed a novel bilirubin adsorbent, called chitin/graphene oxide (Ch/GO) composite aerogel beads, for efficient, fast and safe removal for bilirubin. The Ch/GO aerogel beads were prepared from chitin and GO in a NaOH/urea aqueous solution, followed dried by supercritical carbon dioxide. The morphology, structure and properties of the Ch/GO composite aerogel beads were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and compressive strength measurement. The results indicated that GO was successfully bound to chitin matrix with enhanced surface area, thermal stability and mechanical strength. The adsorption capacity of Ch/GO composite aerogel beads for bilirubin was examined by UV-Visible spectrophotometry. Moreover, batch adsorption results revealed that the Ch/GO composite aerogel beads showed excellent bilirubin adsorption capacity (484.1 ± 16.9 mg/g) and short adsorption equilibrium time (0.5 h) under optimized condition. Furthermore, the Ch/GO aerogel beads exhibited a lower hemolysis property and improved anticoagulant property. Hence, this work provided a new strategy to develop a novel blood compatible bilirubin adsorbent, which presented good application potential for bilirubin adsorption.

血液中的胆红素过多会引起肝损伤和相关的功能障碍。因此，我们设计并构建了一种新颖的胆红素吸附剂，称为几丁质/氧化石墨烯（Ch / GO）复合气凝胶珠，可高效，快速，安全地去除胆红素。Ch / GO气凝胶珠是由几丁质和GO在NaOH /脲水溶液中制得的，然后用超临界二氧化碳干燥。通过扫描电子显微镜（SEM），布鲁诺-埃米特-泰勒（BET），傅立叶变换红外光谱（FTIR），X射线衍射（XRD）和压缩性对Ch / GO复合气凝胶微珠的形貌，结构和性能进行了表征。强度测量。结果表明GO可以成功地结合到几丁质基质上，具有增加的表面积，热稳定性和机械强度。用紫外可见分光光度法测定了Ch / GO复合气凝胶微珠对胆红素的吸附能力。此外，分批吸附结果表明，在优化条件下，Ch / GO复合气凝胶微珠具有优异的胆红素吸附能力（484.1±16.9 mg / g）和较短的吸附平衡时间（0.5 h）。此外，Ch / GO气凝胶珠表现出较低的溶血性质和改善的抗凝血性质。因此，这项工作为开发一种新型的血液相容性胆红素吸附剂提供了新的策略，该吸附剂为胆红素吸附提供了良好的应用潜力。9 mg / g）和优化条件下较短的吸附平衡时间（0.5 h）。此外，Ch / GO气凝胶珠表现出较低的溶血性质和改善的抗凝血性质。因此，这项工作为开发一种新型的血液相容性胆红素吸附剂提供了新的策略，该吸附剂为胆红素吸附提供了良好的应用潜力。9 mg / g）和优化条件下较短的吸附平衡时间（0.5 h）。此外，Ch / GO气凝胶珠表现出较低的溶血性质和改善的抗凝血性质。因此，这项工作为开发一种新型的血液相容性胆红素吸附剂提供了新的策略，该吸附剂为胆红素吸附提供了良好的应用潜力。