Four new aromatic meroterpenoids, ganocapenoids A–D (1–4), together with twelve known analogues (5–16) were isolated from the fruiting bodies of Ganoderma capense. The structures of new compounds were determined through spectroscopic methods including 1D and 2D NMR and MS analyses. Their absolute configurations were assigned by ECD calculations and specific rotation comparison. The biological activities of these substances toward regulation of lipid metabolism, neurite outgrowth-promoting activity, and AchE inhibition were assessed. Compound 15 was found to be able to block lipid accumulation at a concentration of 20 μM, and compounds 4a, 4b, and 11 show moderate neurite outgrowth-promoting activity at 10 μM, while compounds 3, 6, 11, and 13 exhibit potent AchE inhibition with the IC₅₀ values of 28.6 ± 1.9, 18.7 ± 1.6, 8.2 ± 0.2, 26.0 ± 2.9 μM, respectively.

四个新的芳香meroterpenoids，ganocapenoids A-d（1 - 4），加上12个已知类似物（5 - 16）从子实体中分离薄盖灵芝。通过包括1D和2D NMR和MS分析在内的光谱方法确定了新化合物的结构。它们的绝对配置由ECD计算和特定的旋转比较分配。评估了这些物质对调节脂质代谢，促进神经突增生活性和抑制AchE的生物学活性。发现化合物15能够在20μM的浓度下阻止脂质蓄积，化合物4a和4b，和11示出了中等神经突起伸展促进在10μM的活性，而化合物3，6，11，和13显示出有效的乙酰胆碱酯酶抑制作用的IC ₅₀ 28.6±1.9的值，18.7±1.6，8.2±0.2，26.0±2.9μM ， 分别。