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Efficient drug discovery by rational lead hybridization based on crystallographic overlay
Drug Discovery Today ( IF 7.4 ) Pub Date : 2018-12-04 , DOI: 10.1016/j.drudis.2018.11.021 Shuo Zhang , Jian Zhang , Ping Gao , Lin Sun , Yuning Song , Dongwei Kang , Xinyong Liu , Peng Zhan
中文翻译:
通过基于结晶学叠加的合理的铅杂交技术有效地发现药物
更新日期:2018-12-04
Drug Discovery Today ( IF 7.4 ) Pub Date : 2018-12-04 , DOI: 10.1016/j.drudis.2018.11.021 Shuo Zhang , Jian Zhang , Ping Gao , Lin Sun , Yuning Song , Dongwei Kang , Xinyong Liu , Peng Zhan
In this review, we provide an overview of recent applications of crystallographic overlay-based molecular structure hybridization of lead compounds as a rational strategy for efficient drug discovery, with selected examples, and briefly discuss its advantages compared with other ligand-based methodologies.
中文翻译:
通过基于结晶学叠加的合理的铅杂交技术有效地发现药物
在这篇综述中,我们提供了基于结晶学叠加的铅化合物分子结构杂交作为有效药物发现的合理策略的最新应用的概述,并提供了一些实例,并简要讨论了其与其他基于配体的方法相比的优势。