Abstract Doxorubicin (DOX) is one of the commonly used chemotherapeutic agents, but its clinical use is restricted by systemic toxicity and tumor multidrug resistance. To overcome these barriers, PEG modified trimethyl chitosan based nanoparticles (NPs) were prepared for the coencapsulation and codelivery of DOX and survivin shRNA-expressing plasmid (iSur-pDNA). These NPs with particle sizes of 181.9 nm and zeta potentials of 20.2 mV exhibited a pH-sensitive release of DOX and a sustained release of iSur-pDNA, which exerted significantly enhanced in vivo antitumor efficacies compared with single administration with DOX or iSur-pDNA. The results indicated that combinational administration of chemotherapeutic drugs and genes based on NPs could be promising in cancer therapy.

中文翻译：

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基于 PEG 修饰的三甲基壳聚糖纳米粒子，用于阿霉素和 iSur-pDNA 的共递送

摘要 阿霉素（DOX）是常用的化疗药物之一，但其临床应用受到全身毒性和肿瘤多药耐药性的限制。为了克服这些障碍，制备了基于 PEG 修饰的三甲基壳聚糖纳米粒子 (NPs)，用于 DOX 和表达存活蛋白 shRNA 的质粒 (iSur-pDNA) 的共封装和共递送。这些粒径为 181.9 nm、zeta 电位为 20.2 mV 的纳米颗粒表现出 DOX 的 pH 敏感性释放和 iSur-pDNA 的持续释放，与单次给药 DOX 或 iSur-pDNA 相比，其体内抗肿瘤功效显着增强。结果表明，联合使用基于纳米粒的化疗药物和基因可能在癌症治疗中大有可为。