Lead Generation represents a critical drug discovery phase where chemical starting points and their respective mechanism of action, quality, and potential liabilities are largely predefined. Recent advances such as DNA-encoded libraries or fragment-, chemical biology-, and virtual screening-based approaches are today as common as traditional High Throughput Screening. Innovations in characterizing lead quality have allowed more informed decision-making by discovery teams. The key challenge today is to individually tailor the right mix of methods for each project to facilitate data integration with the purpose of creating multiple high-quality lead series, ultimately translating to reduced chemistry-related pipeline attrition.

中文翻译：

---

潜在客户产生的进展。

潜在客户生成代表了关键的药物发现阶段，其中化学起点及其各自的作用机制，质量和潜在责任在很大程度上已预先确定。DNA编码文库或片段，化学生物学和基于虚拟筛选的方法等最新进展如今与传统的高通量筛选一样普遍。表征铅质量的创新使发现团队能够做出更明智的决策。当前的主要挑战是为每个项目分别量身定制正确的方法组合，以促进数据集成，以创建多个高质量的潜在客户系列，最终转化为与化学相关的管道损耗减少。