The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

中文翻译：

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紫外线辐射引起的 DNA 损伤可预测黑色素瘤的预后。

黑色素瘤基因组以紫外线辐射 (UVR) 诱导的突变为主。它们与疾病进展的相关性尚不清楚。在这里，我们通过突变特征对黑色素瘤进行分类，并确定了十个可预测患者存活率的反复突变的 UVR 特征基因。我们在原发性人类黑色素瘤中验证了这些发现；在小鼠中，我们表明这种特征是由短波 UVR 留下的印记，并且四次暴露于 UVR 足以加速黑色素瘤的形成。