Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed in situ as nucleophiles†,Chemical Science

当前位置： X-MOL 学术 › Chem. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed in situ as nucleophiles†
Chemical Science ( IF 7.6 ) Pub Date : 2018-12-04 00:00:00 , DOI: 10.1039/c8sc04626c
Kun Yao ₁ , Qianjia Yuan ₂ , Xingxin Qu ₁ , Yangang Liu ₁ , Delong Liu ₁ , Wanbin Zhang _{1,

2}

Affiliation

A Pd-catalyzed asymmetric allylic substitution cascade reaction, using α-(pyridin-1-yl)-acetamides (formed in situ) as nucleophiles, has been developed, generating chiral piperidine-containing amino acid derivatives via a one-pot procedure in high yields and with up to 96% ee. The products can be easily converted into potential bioactive compounds, unnatural chiral amino acids and dipeptides.

中文翻译：

使用原位形成的 α-(吡啶-1-基)-乙酰胺作为亲核试剂，Pd 催化的不对称烯丙基取代级联†

开发了一种钯催化的不对称烯丙基取代级联反应，使用α-(吡啶-1-基)-乙酰胺（原位形成）作为亲核试剂，通过一锅法在高温下生成手性含哌啶的氨基酸衍生物。产率高达 96% ee。该产品可以很容易地转化为潜在的生物活性化合物、非天然手性氨基酸和二肽。

更新日期：2018-12-04

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11