1,5-Dideoxy-1,5-imino-l-fucitol (1-deoxyfuconojirimycin, DFJ) is an iminosugar that inhibits fucosidases. Herein, N-alkyl DFJs have been synthesised and tested against the α-fucosidases of T. maritima (bacterial origin) and B. taurus (bovine origin). The N-alkyl derivatives were inactive against the bacterial fucosidase, while inhibiting the bovine enzyme. Docking of inhibitors to homology models, generated for the bovine and human fucosidases, was carried out. N-Decyl-DFJ was toxic to cancer cell lines and was more potent than the other N-alkyl DFJs studied.

中文翻译：

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N-烷基-1,5-二脱氧-1,5-亚氨基-1-岩藻糖醇作为岩藻糖苷酶抑制剂：合成，分子建模和对癌细胞系的活性。

1,5-二脱氧-1,5-亚氨基-1-岩藻糖醇（1-deoxyfuconojirimycin，DFJ）是抑制岩藻糖苷酶的亚氨基糖。在此，已经合成了N-烷基DFJ并针对海里螺旋杆菌（细菌来源）和金牛B.（牛来源）的α-岩藻糖苷酶进行了测试。N-烷基衍生物对细菌岩藻糖苷酶无活性，同时抑制了牛酶。进行了将抑制剂对接至针对牛和人岩藻糖苷酶产生的同源性模型的研究。N-癸基-DFJ对癌细胞系具有毒性，并且比研究的其他N-烷基DFJ更有效。