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Eight new glycosides with hepatoprotective activity isolated from the aerial parts of Morinda parvifolia.
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2018-12-03 , DOI: 10.1016/j.bioorg.2018.11.055 Xianming Su 1 , Li Li 1 , Hua Sun 1 , Fan Zhang 1 , Changkang Li 1 , Fenghua Li 1 , Hongqing Wang 1 , Baoming Li 1 , Ruoyun Chen 1 , Jie Kang 1
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2018-12-03 , DOI: 10.1016/j.bioorg.2018.11.055 Xianming Su 1 , Li Li 1 , Hua Sun 1 , Fan Zhang 1 , Changkang Li 1 , Fenghua Li 1 , Hongqing Wang 1 , Baoming Li 1 , Ruoyun Chen 1 , Jie Kang 1
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Eight new glycosides, morindaparvins P-W, were isolated from the butanol extract of the aerial parts of Morinda parvifolia. These new structures were elucidated by comprehensive spectroscopic analysis and by comparing the experimental and calculated electronic circular dichroism spectra. The butanol extract was observed to significantly reduce the levels of alanine aminotransferase, aspartate transaminase, and lactate dehydrogenase in the sera of mice with concanavalin A-induced hepatitis. At a concentration of 10 μM, five compounds (1, and 4-7) isolated from the butanol extract possessed hepatoprotective activities against the damage induced by acetaminophen in human HepG2 liver cancer cells.
中文翻译：
从巴戟天的地上部分中分离出八种具有保肝活性的新糖苷。
从巴戟天地上部分的丁醇提取物中分离出八种新的糖苷，morindaparvins PW。通过综合光谱分析和比较实验和计算的电子圆二色性光谱，阐明了这些新结构。观察到丁醇提取物可显着降低伴刀豆球蛋白A诱导的肝炎小鼠血清中丙氨酸转氨酶，天冬氨酸转氨酶和乳酸脱氢酶的水平。从丁醇提取物中分离出的5种化合物（1和4-7）的浓度为10μM，具有对人类对HepG2肝癌细胞中对乙酰氨基酚引起的损伤的保肝活性。
更新日期：2018-12-03
中文翻译：
从巴戟天的地上部分中分离出八种具有保肝活性的新糖苷。
从巴戟天地上部分的丁醇提取物中分离出八种新的糖苷，morindaparvins PW。通过综合光谱分析和比较实验和计算的电子圆二色性光谱，阐明了这些新结构。观察到丁醇提取物可显着降低伴刀豆球蛋白A诱导的肝炎小鼠血清中丙氨酸转氨酶，天冬氨酸转氨酶和乳酸脱氢酶的水平。从丁醇提取物中分离出的5种化合物（1和4-7）的浓度为10μM，具有对人类对HepG2肝癌细胞中对乙酰氨基酚引起的损伤的保肝活性。
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