Integrating reactive distillation with continuous flow processing†,Reaction Chemistry & Engineering

当前位置： X-MOL 学术 › React. Chem. Eng. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Integrating reactive distillation with continuous flow processing†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2018-11-30 00:00:00 , DOI: 10.1039/c8re00217g
Marcus Baumann _{1,

2,

3,

4,

5}

Affiliation

A continuous flow platform has been developed that integrates reactive distillation with modern flow reactor technology. This has been applied to the successful flow synthesis of a series of tetrahydroquinolines generated through an InCl₃-catalysed Povarov reaction between different aryl imines and cyclopentadiene that was generated by a continuous distillation from its dimeric precursor via a thermal retro Diels–Alder reaction. The developed continuous process represents a robust approach to these important heterocyclic entities which were prepared on the gram scale within less than one hour.

中文翻译：

将反应蒸馏与连续流处理相结合†

已经开发出将反应蒸馏与现代流动反应器技术整合在一起的连续流动平台。该方法已成功用于一系列四氢喹啉的流合成，该四氢喹啉是通过InCl ₃催化的不同芳基亚胺和环戊二烯之间的Povarov反应生成的，该反应是通过热逆Diels-Alder反应从其二聚体前体连续蒸馏而生成的。所开发的连续过程代表了对这些重要的杂环实体的强大方法，这些实体在不到一小时的时间内就以克为单位进行了制备。

更新日期：2018-11-30

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11