Photodynamic therapy (PDT) is believed to be a potent method for biofilm treatments. However, undesired damage to normal cells may be caused due to the nonselective nature of PDT. Therefore, targeted PDT is preferred on one hand to enhance antimicrobial effects and on the other hand to reduce cytotoxicity to normal cells. For this purpose, novel bacteria‐targeted photosensitizer delivery micelles are fabricated, taking advantage of α‐cyclodextrin (α‐CD)/polyethylene glycol (PEG) supramolecular assembly. Hydrophilic antimicrobial peptide (AMP) Magainin I is covalently bound with PEG, working as a bacterial targeting group as well as the stabilizing shell of the supramolecular micelles. Photosensitizer Chlorin e6 (Ce6) is grafted onto α‐CD. The micelles exhibit excellent bacterial targeting effects. Compared to α‐CD‐Ce6, the supramolecular micelles possess enhanced biofilm killing ability against Gram (−) Pseudomonas aeruginosa biofilms and Gram (+) methicillin‐resistant Staphylococcus aureus (MRSA) biofilms while reducing cytotoxicity to NIH/3T3 model cells.

中文翻译：

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针对生物膜的光动力消融的细菌靶向超分子光敏剂输送载体。

光动力疗法（PDT）被认为是生物膜治疗的有效方法。但是，由于PDT的非选择性性质，可能会对正常细胞造成不希望的损害。因此，一方面优选靶向PDT以增强抗微生物作用，另一方面降低对正常细胞的细胞毒性。为此，利用α-环糊精（α-CD）/聚乙二醇（PEG）超分子组装技术，制造了新型的细菌靶向光敏剂传递胶束。亲水性抗菌肽（AMP）Magainin I与PEG共价结合，可作为细菌靶向基团以及超分子胶束的稳定壳。光敏剂Chlorin e6（Ce6）被接枝到α-CD上。胶束表现出优异的细菌靶向作用。与α‐CD‐Ce6相比，铜绿假单胞菌生物膜和耐甲氧西林金黄色葡萄球菌（MRSA）生物膜，同时减少对NIH / 3T3模型细胞的细胞毒性。