Abstract Poly(1, 8-octanediol citrate) (POC) degradable elastomer have attracted much attention due to its good biological properties. However, there is a compromise, i.e. to improve its extendibility inevitably leads to a sticky feature that causes inconvenient handling. Poly(e-caprolactone) (PCL) is a commonly used biodegradable, flexible polyester applied in a variety of FDA-approved products. Here, an in-situ copolymerization blending strategy, i.e. melt polycondensation of citric acid and 1, 8-octanediol in the presence of PCL was adopted to produce a POC/PCL composite elastomer, in which partial PCL took part in polycondensation reaction and chemically bonded into the POC network, and the rest physically traversed within the network structure, leading to a transparent, flexible composite elastomer. The wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC) analyses confirmed a full-amorphous structure and no crystallization of PCL occurring. Moreover, the introduction of PCL not only improved extendibility but avoided stickiness. Compared to the POC, the time for curing POC/PCL prepolymers was highly reduced; and the degradation of composite elastomers in PBS solution was accelerated despite the slow degradation of PCL incorporated; additionally, surface erosion degradation presumably happened for POC/PCL elastomers, which would allow the implant to retain inner strength for a longer time.

中文翻译：

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原位共聚策略制备的新型POC/PCL可降解复合弹性体

摘要 聚（1, 8-辛二醇柠檬酸酯）（POC）可降解弹性体因其良好的生物学特性而备受关注。但是，有一个折衷方案，即提高其可扩展性不可避免地会导致粘性特征，从而导致操作不便。聚(e-己内酯) (PCL) 是一种常用的可生物降解的柔性聚酯，应用于各种 FDA 批准的产品中。在此，采用原位共聚共混策略，即柠檬酸与 1, 8-辛二醇在 PCL 存在下熔融缩聚制备 POC/PCL 复合弹性体，其中部分 PCL 参与缩聚反应并化学键合进入 POC 网络，其余部分在网络结构内物理穿越，形成透明、灵活的复合弹性体。广角 X 射线衍射 (WAXD) 和差示扫描量热法 (DSC) 分析证实了全非晶结构并且没有发生 PCL 的结晶。此外，PCL 的引入不仅提高了延展性，而且避免了粘性。与POC相比，POC/PCL预聚物的固化时间大大缩短；尽管加入的 PCL 降解缓慢，但复合弹性体在 PBS 溶液中的降解加速；此外，POC/PCL 弹性体可能会发生表面侵蚀退化，这将使植入物能够更长时间地保持内部强度。与POC相比，POC/PCL预聚物的固化时间大大缩短；尽管加入的 PCL 降解缓慢，但复合弹性体在 PBS 溶液中的降解加速；此外，POC/PCL 弹性体可能会发生表面侵蚀退化，这将使植入物能够更长时间地保持内部强度。与POC相比，POC/PCL预聚物的固化时间大大缩短；尽管加入的 PCL 降解缓慢，但复合弹性体在 PBS 溶液中的降解加速；此外，POC/PCL 弹性体可能会发生表面侵蚀退化，这将使植入物能够更长时间地保持内部强度。