Abstract In this work selenium-polyethylene glycol 6000 (PEG6000) composite network was synthesized. Simple and inexpensive one-pot method was performed at room temperature. Saturated water solution of diethyl ether acted as a solvent and ascorbic acid was used as a reduction agent for sodium selenite. Prepared orange selenium-PEG6000 solid composite was characterised by SEM, XRD and TEM measurements. The antibacterial activity of prepared sample was tested on Gram-positive Staphylococcus epidermidis (DBM 2124) and Gram-negative Escherichia coli (DBM 3138). Synthesized material showed antibacterial activity on S. epidermidis, however, E. coli bacteria were not inhibited. Although bulk-like, the material has a large surface area and anti-microbial properties of nano-sized amorphous selenium. Thus it can be used in specific applications, e.g. as a special targeted drug or for selective antimicrobial coating.

中文翻译：

---

具有选择性抗菌活性的无定形纳米硒-PEG复合网络的制备

摘要 本工作合成了硒-聚乙二醇6000（PEG6000）复合网络。在室温下进行简单且廉价的一锅法。乙醚饱和水溶液作为溶剂，抗坏血酸作为亚硒酸钠的还原剂。通过SEM、XRD和TEM测量对制备的橙色硒-PEG6000固体复合物进行表征。制备的样品对革兰氏阳性表皮葡萄球菌（DBM 2124）和革兰氏阴性大肠杆菌（DBM 3138）的抗菌活性进行了测试。合成材料对表皮葡萄球菌有抗菌活性，但对大肠杆菌没有抑制作用。尽管呈块状，但该材料具有纳米级无定形硒的大表面积和抗微生物特性。因此它可以用于特定的应用程序，例如