In this study, in order to assess thermal runaway risk of two step synthesis reactions, two new risk assessment methods were proposed by combining the new assessment procedure with the risk matrix and the Stoessel criticality diagram. The thermal runaway risks of the tert-butyl peroxybenzoate (TBPB) synthesis process and the tert-butyl peracetate (TBPA) synthesis process, and the influence of the use of the pure target products on the assessment results were also studied by the new methods. The results showed that the new methods could obtain more accurate assessment results of two step synthesis reactions. Some measures should be taken to reduce the thermal runaway risks of the two synthesis processes. Furthermore, the use of the pure target products in the new methods would exaggerate the thermal runaway risks of the two step synthesis reactions.

中文翻译：

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两步合成反应的热失控风险评估新方法

在这项研究中，为了评估两步合成反应的热失控风险，通过将新的评估程序与风险矩阵和Stoessel临界图相结合，提出了两种新的风险评估方法。所述的热失控的风险叔丁基过氧苯甲酸酯（TBPB）的合成过程和叔用新方法研究了过乙酸丁酯（TBPA）的合成过程以及纯目标产物的使用对评估结果的影响。结果表明，新方法可以更准确地评估两步合成反应。应该采取一些措施来减少两个合成过程的热失控风险。此外，在新方法中使用纯目标产物会夸大两步合成反应的热失控风险。