Enhanced Photoacoustic and Photothermal Effect of Functionalized Polypyrrole Nanoparticles for Near-Infrared Theranostic Treatment of Tumor.,Biomacromolecules

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Enhanced Photoacoustic and Photothermal Effect of Functionalized Polypyrrole Nanoparticles for Near-Infrared Theranostic Treatment of Tumor.
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-12-10 , DOI: 10.1021/acs.biomac.8b01453
Wenchao Li ₁ , Xingyue Wang ₂ , Jingjing Wang ₁ , Yuan Guo ₂ , Shi-Yu Lu ₁ , Chang Ming Li ₁ , Yuejun Kang _{1,

3} , Zhi-Gang Wang ₂ , Hai-Tao Ran ₂ , Yang Cao ₂ , Hui Liu _{1,

3}

Affiliation

Functionalized nanomaterials with near-infrared (NIR) responsive capacity are quite promising for theranostic treatment of tumors, but formation of NIR responsive nanomaterials with enhanced theranostic ability and excellent biocompatibility is still very challenging. Herein, PEGylated indocyanine green (ICG)-loaded polypyrrole nanoparticles (PPI NPs) were designed and successfully formed through selecting polydopamine as the linkage between each component, demonstrating enhanced NIR responsive theranostic ability against tumor. By combining in vitro cell study with in vivo assay, the formed PPI NPs were proven to be fantastically biocompatible while effectively internalization in HeLa cells and retention in HeLa tumor were demonstrated by in vitro flow cytometry/confocal measurement and in vivo photoacoustic imaging assay. With the guidance of photoacoustic imaging, successful photothermal ablation of tumor was achieved by treatment with PPI NPs plus laser, which was much more effective than the group treated with NPs free of ICG. The combined enhanced photoacoustic and photothermal effect is mainly ascribed to the functionalized polypyrrole nanoparticles, which could accumulate in the tumor site more effectively with a relatively longer retention time taking advantage of the nanomaterial-induced endothelial leakiness phenomenon. All these results demonstrating that this designed PPI NPs possessing enhanced NIR responsive property hold great promise for tumor NIR theranostic applications.

中文翻译：

功能化的聚吡咯纳米粒子在肿瘤的近红外治疗中的增强的光声和光热效应。

具有近红外（NIR）响应能力的功能化纳米材料对于肿瘤的肿瘤治疗非常有前途，但是具有增强的肿瘤治疗能力和出色的生物相容性的NIR响应纳米材料的形成仍然非常具有挑战性。本文中，通过选择聚多巴胺作为各组分之间的连接，设计并成功形成了聚乙二醇化吲哚菁绿（ICG）负载的聚吡咯纳米颗粒（PPI NPs），证明了增强的近红外响应肿瘤治疗能力。通过将体外细胞研究与体内测定相结合，已形成的PPI NPs被证明具有极好的生物相容性，同时通过体外流式细胞术/浓液测定和体内光声成像测定证明了在HeLa细胞中的有效内在化和在HeLa肿瘤中的保留。在光声成像的指导下，通过用PPI NPs加激光治疗成功实现了肿瘤的光热消融，这比用不含ICG的NPs治疗组要有效得多。结合的增强的光声和光热作用主要归因于官能化的聚吡咯纳米颗粒，其可以利用纳米材料诱导的内皮渗漏现象以相对较长的保留时间更有效地积聚在肿瘤部位。所有这些结果表明，这种设计的具有增强的近红外响应特性的PPI NP在肿瘤近红外治疗学应用中具有广阔的前景。这比用不含ICG的NP治疗的组要有效得多。结合的增强的光声和光热作用主要归因于官能化的聚吡咯纳米颗粒，其可以利用纳米材料诱导的内皮渗漏现象以相对较长的保留时间更有效地积聚在肿瘤部位。所有这些结果表明，这种设计的具有增强的近红外响应特性的PPI NP在肿瘤近红外治疗学应用中具有广阔的前景。这比用不含ICG的NP治疗的组要有效得多。结合的增强的光声和光热作用主要归因于官能化的聚吡咯纳米颗粒，其可以利用纳米材料诱导的内皮渗漏现象以相对较长的保留时间更有效地积聚在肿瘤部位。所有这些结果表明，这种设计的具有增强的近红外响应特性的PPI NP在肿瘤近红外治疗学应用中具有广阔的前景。

更新日期：2018-11-28

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