Abstract Surface modification is an effective method to improve the anti-platelets property for blood-contacting biomedical materials. However, for elastomer it is still a challenge to develop a simple and versatile method to preserve desirable property of the modified surface upon repeated deformation. Herein, we synthesized a novel modifier based on the photoreactive benzophenone (BP), which is served as anchor to fix polyethylene glycols (PEG)s onto polymer surface so as to achieve durable anti-platelets surface. Upon ultra-violet (UV) exposure for a very short time, this modifier (BP-PEG) was chemically bonded onto polyurethane (PU) so that its surface property was improved. When increasing the molecular weight or incorporating sulfonate group into BP-PEG, the anti-platelets surface of PU was obtained and this property still could be preserved upon repeated deformation. The universality of this surface modifier was verified by its successful application to the other polymer substrates and improved hydrophilicity. We anticipate this work would pave a new way to construct durable surface with unique property for biomedical devices.

中文翻译：

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光反应性二苯甲酮作为改性剂的锚定剂构建耐用的抗血小板聚合物表面

摘要 表面改性是提高血液接触生物医学材料抗血小板性能的有效方法。然而，对于弹性体来说，开发一种简单而通用的方法来在反复变形时保持改性表面的理想特性仍然是一个挑战。在此，我们合成了一种基于光反应性二苯甲酮 (BP) 的新型改性剂，作为锚将聚乙二醇 (PEG) 固定在聚合物表面上，从而实现持久的抗血小板表面。在紫外线 (UV) 暴露很短的时间后，这种改性剂 (BP-PEG) 会化学键合到聚氨酯 (PU) 上，从而改善了其表面性能。当增加分子量或在 BP-PEG 中加入磺酸基时，获得了PU的抗血小板表面，在反复变形后仍能保持这种性能。这种表面改性剂的通用性通过其在其他聚合物基材上的成功应用和改进的亲水性得到了验证。我们预计这项工作将为构建具有独特性能的生物医学设备的耐用表面铺平道路。