Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes,Journal of Agricultural and Food Chemistry

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Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-11-28 00:00:00 , DOI: 10.1021/acs.jafc.8b05193
Yanli Liu ₁ , Jing Shen ₁ , Xin Yang ₁ , Qingzhu Sun ₁ , Xiaojun Yang ₁

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Abdominal fat or fatty liver cause huge economic losses in the poultry industry, and nonalcoholic fatty liver disease (NAFLD) is also a global health issue in humans. More than 90% of de novo lipogenesis in humans and chickens is undertaken by the liver, which is proved to be full of lipids in new-born chickens. Folic acid was thought to have correlation with lipid metabolism. Primary hepatocytes from new-born chickens were employed as a natural model of early stage fatty liver in vitro and further to explore whether folic acid could prevent fatty liver in the current study. We found that folic acid addition reduced triglyceride deposition by suppressing de novo fatty acid synthesis and coordinately promoting triglyceride hydrolysis and exportation in primary chicken hepatocytes from new-born chickens. In addition, lipogenesis suppression was through the PI3K/AKT/SREBP pathway mediated by weakening insulin/IGF signal. Our data suggested that folic acid may be considered as a precautionary strategy for abdominal fat deposition in broilers or fatty liver in laying hens and humans. In addition, mechanism regulation also implied that an IGF2 inhibitor and PI3K inhibitor may be used for the NAFLD precautionary measure to reduce TG deposition.

中文翻译：

叶酸减少鸡原代肝细胞中甘油三酸酯的沉积

腹部脂肪或脂肪肝在禽业中造成巨大的经济损失，非酒精性脂肪肝疾病（NAFLD）也是人类的全球健康问题。人类和鸡中超过90％的新生脂肪形成是由肝脏承担的，事实证明，新生鸡中的脂质中充满了脂质。叶酸被认为与脂质代谢有关。将新生鸡的原代肝细胞用作体外早期脂肪肝的天然模型，并在当前研究中进一步探讨叶酸是否可以预防脂肪肝。我们发现，叶酸的添加通过抑制新生脂肪酸的合成和协调促进新生鸡的原代鸡肝细胞中甘油三酸酯的水解和输出而减少了甘油三酸酯的沉积。此外，通过抑制胰岛素/ IGF信号介导的PI3K / AKT / SREBP途径抑制脂肪形成。我们的数据表明，叶酸可被视为蛋鸡和人类肉鸡或脂肪肝中腹部脂肪沉积的预防策略。另外，机制调节还暗示IGF2抑制剂和PI3K抑制剂可用于NAFLD预防措施以减少TG沉积。

更新日期：2018-11-28

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