Abstract The paper shows very systematic method of selection of derivatisation agents for a given group of analytes. In this study 8 derivatisation agents are assessed for their capability to derivatise 8 chlorophenols. Multicriteria decision analysis is used to combine many objectives of derivatisation agents selection into single, easy to be interpreted numerical value. Three basic analyses were performed to obtain rankings with the aims to assess derivatisation reaction, chromatographic separation of derivatised analytes and greenness of derivatisation agents. The first assessment showed acetic anhydride to be the most favourable alternative, the second one indicated N,O‑bis(trimethylsilyl)trifluoroacetamide (BSTFA) - chlorotrimethylsilane (TMCS) mixture to give the best separation and the third proved heptafluorobutyrylimidazole (HFBI) to be the greenest agent. Fourth, comprehensive assessment showed BSTFA:TMCS to have the best total performance. Multicriteria decision analysis can be successfully applied in analytical procedure multi-objective optimisation, at the stage of derivatisation agent selection.

中文翻译：

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多标准决策分析法选择用于氯酚测定的衍生剂

摘要 本文展示了为给定的一组分析物选择衍生剂的非常系统的方法。在本研究中，评估了 8 种衍生剂衍生 8 种氯酚的能力。多标准决策分析用于将衍生剂选择的许多目标组合成单一的、易于解释的数值。进行了三个基本分析以获得排名，目的是评估衍生反应、衍生分析物的色谱分离和衍生剂的绿色度。第一次评估表明乙酸酐是最有利的替代品，第二次评估表明 N，O-双（三甲基甲硅烷基）三氟乙酰胺 (BSTFA) - 三甲基氯硅烷 (TMCS) 混合物提供最佳分离效果，第三个证明七氟丁酰咪唑 (HFBI) 是最环保的试剂。第四，综合评估显示BSTFA:TMCS具有最好的综合性能。多标准决策分析可以成功地应用于分析程序多目标优化，在衍生剂选择阶段。