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Titanium dioxide nanofibers induce angiogenic markers and genomic instability in lung cells leading to a highly dedifferentiated and fibrotic tumor formation in a xenograft model
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2018-11-26 , DOI: 10.1039/c8en01078a
Estefany I. Medina-Reyes 1, 2, 3, 4, 5 , Norma L. Delgado-Buenrostro 1, 2, 3, 4, 5 , Alejandro Déciga-Alcaraz 1, 2, 3, 4, 5 , Verónica Freyre-Fonseca 1, 2, 3, 4, 5 , José O. Flores-Flores 3, 6, 7, 8, 9 , Rogelio Hernández-Pando 5, 9, 10, 11 , Jorge Barrios-Payán 5, 9, 10, 11 , Julio C. Carrero 3, 8, 12, 13, 14 , Yesennia Sánchez-Pérez 5, 15, 16, 17 , Claudia M. García-Cuéllar 5, 15, 16, 17 , Felipe Vaca-Paniagua 1, 2, 3, 4, 5 , Yolanda I. Chirino 1, 2, 3, 4, 5
Affiliation  

Lung adenocarcinoma cells exposed to TiO2nanofibers enhanced tumor characteristics including angiogenic markers and genomic instability, and these cells can even acquire a more aggressive phenotype when grown in a xenograft nude mouse model.



中文翻译:

二氧化钛纳米纤维诱导肺细胞中的血管生成标记物和基因组不稳定性,导致异种移植模型中高度去分化和纤维化肿瘤的形成

暴露于TiO 2纳米纤维的肺腺癌细胞增强了肿瘤特征,包括血管生成标记物和基因组不稳定性,并且这些细胞在异种移植裸鼠模型中生长时甚至可以获得更具侵袭性的表型。

更新日期:2018-11-26
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