The Dose–Response Effect of Lycopene on Cerebral Vessel and Neuron Impairment Induced by Hyperlipidemia,Journal of Agricultural and Food Chemistry

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The Dose–Response Effect of Lycopene on Cerebral Vessel and Neuron Impairment Induced by Hyperlipidemia
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-11-26 00:00:00 , DOI: 10.1021/acs.jafc.8b05232
Wei Wang ₁ , Weichun Yang ₁ , Ziyi Shen ₂ , Sixian Wen ₁ , Minyu Hu ₁

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To study the dose–response effect of lycopene on vessel and neuron damage in the brain against hyperlipidemia, rats were fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw^–1/d^–1. At the end of the fourth week, lycopene doses and serum lycopene concentration showed an inverse U-shape curve. Serum lycopene concentration was negatively correlated with the levels of serum TC, TG, LDL-C, as well as the cerebral LDL-C, VEGF, and VCAM-1. Serum lycopene concentration was positively correlated with the expression of Claudin-5 and the number of neurons in hippocampal CA1 and CA3. Lycopene could also reduce the pathologic change of these areas. These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia.

中文翻译：

番茄红素对高脂血症引起的脑血管和神经元损伤的剂量反应作用

为了研究番茄红素对脑部对高脂血症的血管和神经元损害的剂量反应，给大鼠喂了高胆固醇饲料，并以5、25、45、65、85和105的剂量通过管饲法对番茄红素进行了口服处理， 125 mg / kg / bw ^–1 / d ^–1。在第四周末，番茄红素剂量和血清番茄红素浓度呈倒U形曲线。血清番茄红素浓度与血清TC，TG，LDL-C以及脑LDL-C，VEGF和VCAM-1呈负相关。血清番茄红素浓度与海马CA1和CA3中Claudin-5的表达以及神经元数量呈正相关。番茄红素还可以减少这些区域的病理变化。这些结果表明番茄红素的剂量与血清浓度之间呈反U型关系，而中等剂量最有效地保护脑血管和神经元免受高脂血症的损害。

更新日期：2018-11-26

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