Tea Polysaccharides as Potential Therapeutic Options for Metabolic Diseases,Journal of Agricultural and Food Chemistry

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Tea Polysaccharides as Potential Therapeutic Options for Metabolic Diseases
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-11-26 00:00:00 , DOI: 10.1021/acs.jafc.8b05338
Guijie Chen , Rongshun Chen , Dan Chen , Hong Ye , Bing Hu , Xiaoxiong Zeng , Zhonghua Liu _{1,

2}

Affiliation

Tea polysaccharides (TPS) are regarded as some of the main bioactive constituents of tea made from the leaves and buds of the tea plant (Camellia sinensis L.). An increasing number of studies have demonstrated that TPS can reduce the risk of type 2 diabetes, obesity, and other metabolic diseases. However, the potential mechanisms responsible for antidiabetic and antiobesogenic activities of TPS remain unclear. Therefore, the cellular and physiological mechanisms that underlie the antidiabetic and antiobesogenic effects, including antioxidant and anti-inflammation effects, inhibition of digestive enzymes, prevention of macronutrient absorption, and expression of gene and protein, were summarized in this review. Furthermore, the gastrointestinal functions of TPS and the role of gut microbiota in the prevention and treatment of metabolic diseases were discussed. It is expected that the present review will be helpful for enhancing our knowledge about the health-promoting effects of TPS on metabolic diseases and stimulating further works on TPS.

中文翻译：

茶多糖作为代谢性疾病的潜在治疗选择

茶多糖（TPS）被认为是由茶树（茶花）的叶和芽制成的茶的一些主要生物活性成分。L.）。越来越多的研究表明，TPS可以降低2型糖尿病，肥胖症和其他代谢性疾病的风险。但是，尚不清楚TPS的抗糖尿病和抗肥胖活性的潜在机制。因此，本综述总结了抗糖尿病和抗肥胖作用的细胞和生理机制，包括抗氧化剂和抗发炎作用，抑制消化酶，防止大量营养物质吸收以及基因和蛋白质的表达。此外，还讨论了TPS的胃肠功能以及肠道菌群在预防和治疗代谢性疾病中的作用。

更新日期：2018-11-26

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