An expeditious and highly efficient continuous-flow process was developed for the synthesis of 3-(mesitylthio)-1H-1,2,4-triazole. The starting material 2,4,6-trimethylaniline was diazotized to give diazonium chloride, followed by azo-coupling with 1H-1,2,4-triazole-3-thiol and dediazoniation to provide 3-(mesitylthio)-1H-1,2,4-triazole in 85% yield with a productivity of 344 g/h. The side reactions such as hydrolysis, dimerization, and intramolecular coupling were significantly inhibited by the continuous-flow technology.

中文翻译：

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使用连续流反应器将2,4,6-三甲基苯胺转化为3-（间甲硫基）-1 H -1,2,4-三唑

开发了一种快速且高效的连续流方法，用于合成3-（间甲硫基）-1 H -1,2,4-三唑。起始原料2,4,6-三甲基苯胺重氮化，得到重氮氯化物，接着偶氮耦合用1个ħ -1,2,4-三唑-3-硫醇和dediazoniation以提供3-（mesitylthio）-1 ħ - 1,2,4-三唑的产率为85％，生产率为344 g / h。连续流动技术显着抑制了诸如水解，二聚化和分子内偶联等副反应。