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Lubrication and Wear Protection of Micro-Structured Hydrogels Using Bioinspired Fluids.
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-12-04 , DOI: 10.1021/acs.biomac.8b01311 Jimmy Faivre 1, 2 , Alexandra Montembault 1 , Guillaume Sudre 1 , Buddha Ratna Shrestha 2 , Guojun Xie 3 , Krzysztof Matyjaszewski 3 , Stéphane Benayoun 4 , Xavier Banquy 2 , Thierry Delair 1 , Laurent David 1
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-12-04 , DOI: 10.1021/acs.biomac.8b01311 Jimmy Faivre 1, 2 , Alexandra Montembault 1 , Guillaume Sudre 1 , Buddha Ratna Shrestha 2 , Guojun Xie 3 , Krzysztof Matyjaszewski 3 , Stéphane Benayoun 4 , Xavier Banquy 2 , Thierry Delair 1 , Laurent David 1
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We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid and antiwear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial fluid is composed of sodium hyaluronate (HA) and a bottle-brush polymer (BB) having a polycationic attachment group and polyzwitterionic pendant chains. The 2.5%w/w chitosan hydrogel plugs are organized in a bilayered structure exposing a thin and dense superficial zone (SZ), covering a porous deep zone (DZ), and exhibiting microchannels perpendicularly aligned to the SZ. Using a low-load tribometer, the addition of HA lubricating solution at the hydrogel-hydrogel rubbing contact drastically decreased the coefficient of friction (CoF) from μ = 0.20 ± 0.01 to 0.04 ± 0.01 on the DZ configuration and from μ = 0.31 ± 0.01 to 0.08 ± 0.01 on the SZ surface when increasing the HA concentration from 0 to 1000 μg/mL and its molecular mass from 10 to 1500 kDa, similar to what was found when using the BB polymer alone. When combining the BB polymer and the 1500 kDa HA, the CoF remained stable at μ = 0.04 ± 0.01 for both studied contact configurations, highlighting the synergistic interaction of the two macromolecules. Hydrogel wear was characterized by assessing the final gel surface roughness by the means of an interferometer. Increasing HA concentration and molecular weight plus the addition of the BB polymer led to a dramatic surface wear protection with a final gel surface roughness of the hydrogels similar to the untested gels. In brief, the BB polymer in combination with high molecular weight HA is a potential lubricating fluid as well as a wear resistant agent for soft materials lubrication and wear protection.
中文翻译：
使用生物启发性流体对微结构水凝胶进行润滑和磨损防护。
我们报道了在软和多孔壳聚糖水凝胶tribopairs用作润滑液和抗磨剂的生物启发性滑液的制造和使用。该合成滑液由透明质酸钠（HA）和具有聚阳离子连接基团和聚两性离子侧链的洗瓶刷聚合物（BB）组成。2.5％w / w的壳聚糖水凝胶塞以双层结构组织，露出薄而致密的表层区域（SZ），覆盖了多孔深层区域（DZ），并显示了与SZ垂直对齐的微通道。使用低负荷摩擦计，在水凝胶-水凝胶摩擦接触点处添加HA润滑液可将DZ配置的摩擦系数（CoF）从μ= 0.20±0.01大幅降低至0.04±0.01，从μ= 0.31±0.01到0.08±0。当HA浓度从0增加到1000μg/ mL，其分子质量从10增加到1500 kDa时，在SZ表面上显示01，这与单独使用BB聚合物时发现的相似。当将BB聚合物和1500 kDa HA结合使用时，对于两种研究的接触构型，CoF均稳定在μ= 0.04±0.01，突出了两个大分子的协同相互作用。通过使用干涉仪评估最终的凝胶表面粗糙度来表征水凝胶的磨损。HA浓度和分子量的增加，再加上BB聚合物的加入，导致了显着的表面磨损保护，其水凝胶的最终凝胶表面粗糙度与未经测试的凝胶相似。简单来说，
更新日期：2018-11-21
中文翻译：
使用生物启发性流体对微结构水凝胶进行润滑和磨损防护。
我们报道了在软和多孔壳聚糖水凝胶tribopairs用作润滑液和抗磨剂的生物启发性滑液的制造和使用。该合成滑液由透明质酸钠（HA）和具有聚阳离子连接基团和聚两性离子侧链的洗瓶刷聚合物（BB）组成。2.5％w / w的壳聚糖水凝胶塞以双层结构组织，露出薄而致密的表层区域（SZ），覆盖了多孔深层区域（DZ），并显示了与SZ垂直对齐的微通道。使用低负荷摩擦计，在水凝胶-水凝胶摩擦接触点处添加HA润滑液可将DZ配置的摩擦系数（CoF）从μ= 0.20±0.01大幅降低至0.04±0.01，从μ= 0.31±0.01到0.08±0。当HA浓度从0增加到1000μg/ mL，其分子质量从10增加到1500 kDa时，在SZ表面上显示01，这与单独使用BB聚合物时发现的相似。当将BB聚合物和1500 kDa HA结合使用时，对于两种研究的接触构型，CoF均稳定在μ= 0.04±0.01，突出了两个大分子的协同相互作用。通过使用干涉仪评估最终的凝胶表面粗糙度来表征水凝胶的磨损。HA浓度和分子量的增加，再加上BB聚合物的加入，导致了显着的表面磨损保护，其水凝胶的最终凝胶表面粗糙度与未经测试的凝胶相似。简单来说，
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