Microfluidics Setup Rapidly Measures Solubility Directly from Powder,Organic Process Research & Development

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Microfluidics Setup Rapidly Measures Solubility Directly from Powder
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-11-21 00:00:00 , DOI: 10.1021/acs.oprd.8b00300
Guillem Peybernès _{1,

2} , Romain Grossier ₁ , Frédéric Villard ₂ , Philippe Letellier ₂ , Mehdi Lagaize ₁ , Nadine Candoni ₁ , Stéphane Veesler ₁

Affiliation

This communication presents a new microfluidics device for solubility measurement based on the generation of saturated solutions starting from powder that is compatible with all solvents and molecules. This device is simple and easily incorporated into any laboratory, even those not specialized in microfluidics. We describe the method used to measure solubility, applied here to the pharmaceutical molecules paracetamol and gliclazide in different solvents. The device rapidly measures the solubility of a compound at a variety of temperatures ranging from 20 to 60 °C using extremely small quantities (here, only 30 mg) of material, with a concentration range from mg/mL to hundreds of mg/mL.

中文翻译：

微流体设置可直接从粉末中快速测量溶解度

该交流提出了一种新的微流控装置，用于基于溶解度的生成（从与所有溶剂和分子兼容的粉末开始）来测量溶解度。该设备简单易行，可轻松集成到任何实验室中，即使不是专门从事微流体技术的实验室也是如此。我们描述了用于测量溶解度的方法，在此将其应用于在不同溶剂中的对乙酰氨基酚和格列齐特的药物分子。该设备可在20至60°C的各种温度下使用极少量（此处仅为30 mg）的材料（浓度范围为mg / mL至数百mg / mL）快速测量化合物的溶解度。

更新日期：2018-11-21

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