We report a facile and effective method to fabricate clickable alkyne-functionalized cellulose fibers (ACFs) through in situ chemical oxidation copolymerization of 3-ethynylaniline and aniline under acidic aqueous solution. The effects of process variables on copolymer deposition onto CFs were investigated and suitable preparation conditions were identified. It was found that aniline significantly facilitated the polymerization of 3-ethynylaniline and shortened the preparation time of ACFs from 48 to 6 h. Antibacterial-modified cellulose fibers were prepared by binding β-cyclodextrin (β-CD) to cellulose fibers via click chemistry, followed by the inclusion of ciprofloxacin hydrochloride (CipHCl). The loading and releasing behaviors of CipHCl into/from click product (ACFs@Azide-β-CD) were also revealed. The load amount of CipHCl into ACFs@Azide-β-CD increased remarkably, and the release of CipHCl from ACFs@Azide-β-CD was prolonged. The ACFs@Azide-β-CD loaded with CipHCl exhibited higher and longer-term antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureu) compared with CFs and ACFs.

我们报告了一种简便有效的方法，通过在酸性水溶液中3-乙炔基苯胺和苯胺的原位化学氧化共聚制备可点击的炔烃官能化纤维素纤维（ACF）。研究了工艺变量对共聚物在CF上沉积的影响，并确定了合适的制备条件。发现苯胺显着促进了3-乙炔基苯胺的聚合，并将ACF的制备时间从48小时缩短至6小时。通过点击化学将β-环糊精（β-CD）与纤维素纤维结合，然后加入盐酸环丙沙​​星（CipHCl），来制备抗菌改性的纤维素纤维。还揭示了CipHCl在点击产品（ACFs @Azide-β-CD）中的负载和释放行为。CipHCl在ACFs @叠氮化物-β-CD中的负载量显着增加，并且CipHCl从ACFs @叠氮化物-β-CD中的释放延长。载有CipHCl的ACFs @Azide-β-CD表现出更高和更长期的抗菌活性大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureu）与CF和ACF的比较。