Severe intrauterine adhesions (IUAs) have a great negative impact on women's psychological and reproductive health. It remains a significant challenge to prevent postoperative IUAs because of the complications of various clinical preventive measures and incompatibility of uterine cavity morphology. Herein, we present a new drug-loadedporous scaffold based on a microfluidic droplet template, which combines the characteristics of the artificial biocompatible material GelMA and the natural polysaccharide material Na-alginate. By changing the containers that collect the microfluidic droplets, the porous scaffold conforming to the shape of the uterine cavity could be obtained. The porous structure, mechanical property, and flexibility impart the scaffold with compressibility and send it to the uterus through the vagina. In addition, the external-internal connected open structures could load and control the release of drugs to repair the damaged region continuously in vivo. To verify the antiadhesion and repair of drug-loaded porous scaffolds, we tested the system in the rat model of IUAs, and it was demonstrated that the system had the ability to improve neovascularization, cellularize the damaged tissue, and repair the endometrium. These features provide the drug-loaded porous scaffolds with new options for the improvement of postoperative IUAs. STATEMENT OF SIGNIFICANCE: Intrauterine adhesions are caused by various causes of damage to the endometrial basal layer, thus leading to part or entire adhesions in the cervical or uterine cavity. Clinically, various preventive measures reach the barrier effect through the physical barrier, which are difficult to further promote the repair of the damaged endometrium, and most of them have apparent side effects. This study aims to prepare compressible and biodegradable three-dimensional porous drug-loading biological scaffolds. GelMA and Na-alginate have desirable biocompatibility. The interconnect porous scaffolds, which were prepared through the combination of biomaterials and single emulsion microfluidics, not only have compressibility but also provide space for drug delivery and release. This system can further promote the repair of the endometrium while preventing adhesion.

中文翻译：

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液滴微流控的多孔支架可防止子宫内粘连。

严重的子宫内粘连（IUA）对妇女的心理和生殖健康有很大的负面影响。由于各种临床预防措施的并发症以及子宫腔形态的不相容性，预防术后IUA仍然是一项重大挑战。在本文中，我们提出了一种基于微流体液滴模板的新型载药多孔支架，该支架结合了人工生物相容性材料GelMA和天然多糖材料海藻酸钠的特性。通过改变收集微流体液滴的容器，可以获得符合子宫腔形状的多孔支架。多孔结构，机械性能和柔韧性使支架具有可压缩性，并通过阴道将其发送至子宫。此外，内外相连的开放结构可以负载并控制药物的释放，从而在体内连续修复受损区域。为了验证载药多孔支架的抗粘附和修复作用，我们在IUAs大鼠模型中测试了该系统，并证明该系统具有改善新血管形成，使受损组织细胞化和修复子宫内膜的能力。这些特征为载药的多孔支架提供了改善术后IUA的新选择。意义声明：子宫内粘连是由于多种原因导致子宫内膜基底层受损，从而导致子宫颈或子宫腔的部分或全部粘连。临床上，各种预防措施都是通过物理屏障达到屏障作用的，它们难以进一步促进受损子宫内膜的修复，并且大多数具有明显的副作用。本研究旨在制备可压缩和可生物降解的三维多孔载药生物支架。GelMA和海藻酸钠具有理想的生物相容性。通过生物材料和单乳液微流体的组合制备的互连多孔支架，不仅具有可压缩性，而且还提供了用于药物递送和释放的空间。该系统可以在防止粘连的同时进一步促进子宫内膜的修复。通过生物材料和单乳液微流体的组合制备的互连多孔支架，不仅具有可压缩性，而且还提供了用于药物递送和释放的空间。该系统可以在防止粘连的同时进一步促进子宫内膜的修复。通过生物材料和单乳液微流体的组合制备的互连多孔支架，不仅具有可压缩性，而且还提供了用于药物递送和释放的空间。该系统可以在防止粘连的同时进一步促进子宫内膜的修复。