Detergent effects on lipid bilayers of artificial and biological membranes at subsolubilizing concentrations are known to include the membrane permeabilization which manifests itself through both a flip-flop of detergent molecules from the outer monolayer to the inner monolayer and the membrane leakage of entrapped solutes. We have explored the current fluctuations occurring in planar BLM of asolectin in the presence of ionic detergent SDS at subsolubilizing concentration. Two groups of current fluctuations which the average duration differs by two orders of magnitude can be distinguished. We assume that these differences in the duration of current fluctuations are associated with a different number of SDS molecules in the walls of the putative toroidal hydrophilic pores. We associated short pulses with the formation of short-lived lipid hydrophilic pores. Impulses of greater duration (steps) were associated with the formation of hydrophilic pores, the walls of which contain detergent. Taking into account the characteristics of these pores, we estimated the pore energy, as well as the edge energy of these two kinds of pores. We believe that the flip-flop of SDS molecules in liposomes is provided by long-lived pores, and the contents of the liposome leakage occurs through all pores.

已知在亚增溶浓度下对人造膜和生物膜的脂质双层的去污作用包括膜透化作用，其通过洗涤剂分子从外单层到内单层的翻转以及截留的溶质的膜泄漏而表现出来。我们已经研究了在亚溶解浓度的离子型去污剂SDS存在下，Asolectin平面BLM中发生的电流波动。可以区分出平均持续时间相差两个数量级的两组电流波动。我们假设电流波动持续时间的这些差异与假定的环形亲水性孔壁中SDS分子数量的不同有关。我们将短脉冲与短寿命的脂质亲水性孔的形成相关联。持续时间较长（步骤）的冲动与亲水孔的形成有关，亲水孔的壁中含有去污剂。考虑到这些孔的特征，我们估算了这两种孔的孔能量以及边缘能。我们认为脂质体中SDS分子的触发器是由长寿命的孔提供的，脂质体泄漏的内容物发生在所有孔中。