Polyhedral oligomeric silsesquioxane reinforced poly (L-lactic acid) nanocomposites (PLLA/POSS) were prepared to overcome the insufficient mechanical properties of PLLA. In order to improve the compatibility between the nanofillers and matrix, PLLA chains were grafted onto the POSS nanoparticles via microwave-assisted ring opening polymerization (ROP). Herein, a series of interface-modified polyhedral oligomeric silsesquioxane (POSS-(PLLA)₃₂) nanoparticles with various PLLA tail lengths were synthesized and the influence of the structure and additional amount of POSS nanoparticles on the properties of PLLA based nanocomposites were studied. POSS nanoparticles exhibit effective nucleation activity and lead to a significant improvement in the mechanical strength, thermal stability and biocompatibility of the resulting nanocomposites. The addition of 6 wt% POSS-(PLLA)₃₂ 600 shows the optimal mechanical properties owing to has the longest PLLA tail length on POSS core, which possesses the optimal interfacial compatibility between POSS nanoparticles and PLLA. The Young's modulus improved by 57% and the tensile strength increased by 26.5% compared with neat PLLA. Moreover, the introduction of POSS nanoparticles lead to a porous fiber structure when processed by electrospinning and the nanofibrous scaffold effectively promoted cells adhesion and spreading. These results demonstrate the potential applications of the PLLA/POSS nanocomposites in tissue engineering and regenerative medicine.

制备了多面体低聚倍半硅氧烷增强的聚（L-乳酸）纳米复合材料（PLLA / POSS），以克服PLLA不足的机械性能。为了提高纳米填料与基质之间的相容性，通过微波辅助的开环聚合（ROP）将PLLA链接枝到POSS纳米颗粒上。本文中，一系列界面改性的多面体低聚倍半硅氧烷（POSS-（PLLA）₃₂）合成了具有不同PLLA尾长的纳米粒子，研究了POSS纳米粒子的结构和添加量对PLLA基纳米复合材料性能的影响。POSS纳米颗粒表现出有效的成核活性，并导致所得纳米复合材料的机械强度，热稳定性和生物相容性得到显着改善。添加6 wt％的POSS-（PLLA）₃₂图600显示了最佳的机械性能，这是由于在POSS核心上具有最长的PLLA尾部长度，而POLA纳米粒子与PLLA之间具有最佳的界面相容性。与纯PLLA相比，杨氏模量提高了57％，拉伸强度提高了26.5％。而且，当通过电纺丝加工时，POSS纳米颗粒的引入导致多孔纤维结构，并且纳米纤维支架有效地促进细胞粘附和扩散。这些结果证明了PLLA / POSS纳米复合材料在组织工程和再生医学中的潜在应用。