Abstract Graphene nanoplatelets (GNP) as fillers and Chlorhexidine (CHX), as an antibacterial agent, were incorporated in a polycaprolactone (PCL) matrix and processed into filaments by melt spinning. The influence of both drawing and formulation on the processability, spinnability, mechanical properties and release behaviour of these materials were deeply investigated by performing rheological, morphological analysis, tensile tests, and by measuring the cumulative release of CHX in PBS at 37 °C. Furthermore, Korsmeyer–Peppas model was adopted to study the kinetics release mechanism. The results showed that adding GNP did not alter the processability and spinnability of the systems. Furthermore, a monotonic trend of all of the properties investigated was found as a function of GNP/CHX ratio and DR: stiffness and tensile strength of such fibers were found to increase, and the release behaviour proved to be tunable. In fact, upon increasing GNP content, burst was progressively hindered at the initial stage of release, while being progressively enhanced the kinetics and amount of CHX at the final stage.

中文翻译：

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从含有石墨烯纳米片的聚己内酯基长丝中可调节释放氯己定

摘要 石墨烯纳米片（GNP）作为填料和氯己定（CHX）作为抗菌剂，被掺入聚己内酯（PCL）基质中，并通过熔融纺丝加工成细丝。通过流变学、形态分析、拉伸试验以及测量 37 °C 下 CHX 在 PBS 中的累积释放，深入研究了拉伸和配方对这些材料的可加工性、可纺性、机械性能和释放行为的影响。此外，采用 Korsmeyer-Peppas 模型来研究动力学释放机制。结果表明，添加 GNP 不会改变系统的可加工性和可纺性。此外，发现所研究的所有特性的单调趋势是 GNP/CHX 比率和 DR 的函数：发现此类纤维的刚度和拉伸强度增加，并且释放行为证明是可调的。事实上，随着 GNP 含量的增加，爆发在释放的初始阶段逐渐受到阻碍，而在最后阶段逐渐增强了 CHX 的动力学和数量。