Exposure to childhood trauma (CT) increases the risk for psychosis and affects the development of brain structures, possibly through oxidative stress. As oxidative stress is also linked to psychosis, it may interact with CT, leading to a more severe clinical phenotype. In 133 patients with early psychosis (EPP), we explored the relationships between CT and hippocampal, amygdala, and intracranial volume (ICV); blood antioxidant defenses [glutathione peroxidase (GPx) and thioredoxin/peroxiredoxin (Trx/Prx)]; psychopathological results; and neuropsychological results. Nonadjusted hippocampal volume correlated negatively with GPx activity in patients with CT, but not in patients without CT. In patients with CT with high GPx activity (high-GPx+CT), hippocampal volume was decreased compared with that in patients with low-GPx+CT and patients without CT, who had similar hippocampal volumes. Patients with high-GPx+CT had more severe positive and disorganized symptoms than other patients. Interestingly, Trx and oxidized Prx levels correlated negatively with GPx only in patients with low-GPx+CT. Moreover, patients with low-GPx+CT performed better than other patients on cognitive tasks. Discriminant analysis combining redox markers, hippocampal volume, clinical scores, and cognitive scores allowed for stratification of the patients into subgroups. In conclusion, traumatized EPP with high peripheral oxidation status (high-GPx activity) had smaller hippocampal volumes and more severe symptoms, while those with lower oxidation status (low-GPx activity) showed better cognition and regulation of GPx and Trx/Prx systems. These results suggest that maintained regulation of various antioxidant systems allowed for compensatory mechanisms preventing long-term neuroanatomical and clinical impacts. The redox marker profile may thus represent important biomarkers for defining treatment strategies in patients with psychosis.

暴露于儿童期创伤（CT）可能会增加精神病的风险，并可能通过氧化应激影响大脑结构的发育。由于氧化应激也与精神病有关，它可能与CT相互作用，导致更严重的临床表型。在133例早期精神病（EPP）患者中，我们探讨了CT与海马，杏仁核和颅内体积（ICV）之间的关系。血液中的抗氧化剂防御措施[谷胱甘肽过氧化物酶（GPx）和硫氧还蛋白/过氧化物酶（Trx / Prx）]；心理病理结果；和神经心理学结果。CT患者未经调节的海马体积与GPx活性呈负相关，而非CT患者则没有。具有高GPx活性的CT患者（高GPx + CT）的海马体积比低GPx + CT的患者和无CT的患者减少，他们的海马体积相似。高GPx + CT患者比其他患者有更严重的阳性和混乱症状。有趣的是，Trx和氧化的Prx水平仅在低GPx + CT患者中与GPx负相关。此外，低GPx + CT患者在认知任务上的表现优于其他患者。结合氧化还原标记，海马体积，临床评分和认知评分的判别分析可将患者分为亚组。总之，具有高外围氧化状态（高GPx活性）的受创伤的EPP具有较小的海马体积和更严重的症状，而具有较低氧化状态（低GPx活性）的那些EPP表现出对GPx和Trx / Prx系统的更好的认知和调节。这些结果表明，维持各种抗氧化剂系统的调节允许补偿机制防止长期的神经解剖学和临床影响。氧化还原标记物谱因此可以代表重要的生物标记物，用于定义精神病患者的治疗策略。