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Evaluation of the sintering temperature on the mechanical behavior of β-tricalcium phosphate/calcium silicate scaffolds obtained by gelcasting method.
Journal of the Mechanical Behavior of Biomedical Materials ( IF 3.3 ) Pub Date : 2018-11-17 , DOI: 10.1016/j.jmbbm.2018.11.014
Lilian de Siqueira 1 , Cynthia Guimarães de Paula 1 , Rubia Figueredo Gouveia 2 , Mariana Motisuke 1 , Eliandra de Sousa Trichês 1
Affiliation  

Scaffolds have been studied during the last decades as an alternative method to repair tissues. They are porous structures that act as a substrate for cellular growth, proliferation and differentiation. In this study, scaffolds of β-tricalcium phosphate with calcium silicate fibers were prepared by gel casting method in order to be characterized and validated as a better choice for bone tissue treatment. Gel-casting led to scaffolds with high porosity (84%) and pores sizes varying from 160 to 500 µm, which is an important factor for the neovascularization of the growing tissue. Biocompatible and bioactive calcium silicate fibers, which can be successfully produced by molten salt method, were added into the scaffolds as a manner to improve its mechanical resistance and bioactivity. The addition of 5 wt% of calcium silicate fibers associated with a higher sintering temperature (1300 °C) increased by 64.6% the compressive strength of the scaffold and it has also led to the formation of a dense and uniform apatite layer after biomineralization assessment.



中文翻译:

烧结温度对凝胶浇铸法制得的β-磷酸三钙/硅酸钙支架的力学性能的评价。

在过去的几十年中,已经研究了支架作为修复组织的替代方法。它们是多孔结构,可作为细胞生长,增殖和分化的底物。在本研究中,通过凝胶浇铸法制备了β-磷酸三钙与硅酸钙纤维的支架,以对其进行表征并验证其是治疗骨组织的更好选择。凝胶浇铸导致支架具有高孔隙率(84%),孔大小从160到500 µm不等,这是生长组织新血管形成的重要因素。可通过熔融盐法成功生产的具有生物相容性和生物活性的硅酸钙纤维被添加到支架中,以改善其机械强度和生物活性。

更新日期:2018-11-17
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