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Response to "Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method".
Journal of Proteome Research ( IF 4.4 ) Pub Date : 2018-11-20 , DOI: 10.1021/acs.jproteome.8b00871
Brahim Achour 1 , Amin Rostami-Hodjegan 1, 2 , Jill Barber 1
Affiliation  

A recent publication in this journal reported the application of a targeted proteomic strategy using a quantitative concatemer (QconCAT) standard to the assessment of allele-specific expression of UGT2B15 claiming this methodology to be a "novel" approach ( J. Proteome Res. 2018, 17 (10), 3606-3612, DOI: 10.1021/acs.jproteome.8b00620). While the application is not common, the method was previously described and reported by our group in relation to the quantification of CYP2B6 alleles ( J. Proteome Res. 2013, 12 (12), 5934-5942, DOI: 10.1021/pr400279u) to assess the expression of a prevalent polymorphism in a Caucasian population.

中文翻译:

对“使用新型定量基于辅酶的蛋白质组学方法确定等位基因特异性蛋白表达(ASPE)”的响应。

该杂志的最新出版物报道了使用定量连接蛋白(QconCAT)标准的靶向蛋白质组学策略在UGT2B15等位基因特异性表达评估中的应用,声称该方法学是一种``新颖的''方法(J.Proteome Res.2018, 17(10),3606-3612,DOI:10.1021 / acs.jproteome.8b00620)。尽管应用并不普遍,但该方法先前已由我们的小组描述并报告了有关CYP2B6等位基因定量的方法(J.Proteome Res.2013,12(12),5934-5942,DOI:10.1021 / pr400279u)白人人群中普遍多态性的表达。
更新日期:2018-11-21
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