Abstract A series of seven alkali-free silica-based bioactive glasses (SBG) with ZnO and/or SrO additives (in concentrations of 0–12 mol%) were synthesized by melt-quenching, aiming to delineate a candidate formulation possessing (i) a coefficient of thermal expansion (CTE) similar to the one of titanium (Ti) and its medical grade super-alloys (crucial for the future development of mechanically adherent implant-type SBG coatings) and (ii) antibacterial efficiency, while (iii) conserving a good cytocompatibility. The SBGs powders were multi-parametrically evaluated by X-ray diffraction, Fourier transform infrared and micro-Raman spectroscopy, dilatometry, inductively coupled plasma mass spectrometry, antibacterial (against Staphylococcus aureus and Escherichia coli strains) suspension inhibition and agar diffusion tests, and human mesenchymal stem cells cytocompatibility assays. The results showed that the coupled incorporation of zinc and strontium ions into the parent glass composition has a combinatorial and additive benefit. In particular, the “Z6S4” formulation (mol%: SiO2—38.49, CaO—32.07, P2O5—5.61, MgO—13.24, CaF2—0.59, ZnO—6.0, SrO—4.0) conferred strong antimicrobial activity against both types of strains, minimal cytotoxicity combined with good stem cells viability and proliferation, and a CTE (~ 8.7 × 10−6 × °C−1) matching well those of the Ti-based implant materials.

中文翻译：

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结合 ZnO 和/或 SrO 作为治疗剂的无碱生物玻璃的抗菌效率

摘要 通过熔融淬火合成了一系列含有 ZnO 和/或 SrO 添加剂（浓度为 0-12 mol%）的七种无碱二氧化硅基生物活性玻璃（SBG），旨在描绘具有（i）热膨胀系数 (CTE) 类似于钛 (Ti) 及其医用级高温合金之一（对于机械粘附植入式 SBG 涂层的未来发展至关重要）和 (ii) 抗菌效率，同时 (iii)保持良好的细胞相容性。通过 X 射线衍射、傅里叶变换红外和微拉曼光谱、膨胀法、电感耦合等离子体质谱、抗菌（针对金黄色葡萄球菌和大肠杆菌菌株）悬浮抑制和琼脂扩散试验对 SBG 粉末进行了多参数评估，和人类间充质干细胞细胞相容性分析。结果表明，锌和锶离子耦合结合到母体玻璃组合物中具有组合和添加剂益处。特别是，“Z6S4”配方（mol%：SiO2-38.49、CaO-32.07、P2O5-5.61、MgO-13.24、CaF2-0.59、ZnO-6.0、SrO-4.0）对两种类型的菌株都具有很强的抗菌活性，最小的细胞毒性与良好的干细胞活力和增殖相结合，CTE（~ 8.7 × 10−6 × °C−1）与钛基植入材料的CTE非常匹配。