Seven compounds including four undescribed fusaric acid derivatives, namely fusaricates H-K, and two undescribed γ-pyrone derivatives, named fusolanones A-B, as well as a known compound fusaric acid, were isolated from a mangrove endophytic fungus Fusarium solani. Fusaricates H-K represent the first cases of fusaric acid butanediol esters and are diastereoisomers. Their structures including absolute configurations were elucidated based on NMR, MS, chemical synthesis, chiral HPLC analysis and ECD calculations. The antibacterial activity of all undescribed compounds were tested and fusolanone B showed the best activity with MIC value 6.25 μg/mL on Vibrio parahaemolyticus.

中文翻译：

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从红树林内生真菌 Fusarium solani HDN15-410 中 Fusaricates HK 和 Fusolanones AB

从红树林内生真菌 Fusarium solani 中分离出 7 种化合物，包括四种未描述的镰刀菌酸衍生物，即镰刀菌酸 HK，两种未描述的γ-吡喃酮衍生物，名为 Fusolanones AB，以及已知的化合物镰刀菌酸。Fusaricates HK代表了镰刀酸丁二醇酯的第一个例子并且是非对映异构体。基于NMR、MS、化学合成、手性HPLC分析和ECD计算阐明了它们的结构，包括绝对构型。测试了所有未描述的化合物的抗菌活性，呋喃酮 B 对副溶血性弧菌的抗菌活性最好，MIC 值为 6.25 μg/mL。