Abstract Branched polyesters with acid degradable and oxidation responsive β-thiopropionate groups have been obtained by lipase catalyzed polycondensation of diester and hydroxyester monomers from heptanal, a castor oil derivative. Their polymerization behavior has been investigated and poly(ethylene glycol)-b-poly(β-thioether ester) amphiphilic block copolymers have been obtained. SEC, NMR and FTIR have been employed to confirm the structure of the polymers and copolymers and DSC and TGA have been used to characterize their thermal properties. The block copolymers containing aliphatic pendant moieties self-assemble into micelles in aqueous solution, showing potential application as dual responsive systems in drug delivery.

中文翻译：

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蓖麻油酸降解氧化反应性聚（β-硫醚酯）的合成

摘要 通过脂肪酶催化二酯和羟基酯单体从庚醛（一种蓖麻油衍生物）的缩聚反应获得了具有酸可降解性和氧化响应性 β-硫代丙酸酯基团的支化聚酯。研究了它们的聚合行为并获得了聚（乙二醇）-b-聚（β-硫醚酯）两亲嵌段共聚物。SEC、NMR 和 FTIR 已用于确认聚合物和共聚物的结构，DSC 和 TGA 已用于表征它们的热性能。含有脂肪族侧链部分的嵌段共聚物在水溶液中自组装成胶束，显示出在药物递送中作为双响应系统的潜在应用。