Organisms have evolved to produce various natural products from a common precursor as a means of maximizing the number of secondary metabolites, thus acquiring selectional advantages. By adopting nature's divergent biosynthetic strategy, we transformed (+)-catharanthine to various iboga and post-iboga alkaloids, including (−)-conodusine A, (+)-conodusines B and C, (−)-voatinggine, (−)-tabertinggine, and (+)-dippinine B. Well-orchestrated oxidations and reorganizations of catharanthine derivatives enabled chemical access to these natural products.

中文翻译：

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生物合成激发的伊博加向单体后伊博加生物碱的转化。

有机体已经进化为从一种常见的前体中生产出各种天然产物，以此来最大化次生代谢产物的数量，从而获得选择优势。通过采用自然界中多样化的生物合成策略，我们将（+）-catharanthine转化为各种iboga和后iboga生物碱，包括（-）-conodusine A，（+）-conodusines B和C，（-）-voatinggine，（-）- Tabertinggine和（+）-DippinineB。妥善安排的Catharanthine衍生物的氧化和重组使化学方法可以获取这些天然产物。