Resorcinol alkyl glucosides 7–12 were developed as novel tyrosinase inhibitors based on the structure of rhododendrin. These were synthesized from 2,4-dibenzyloxybenzaldehyde using either the Wittig or the Horner-Wadsworth-Emmons reaction with Koenigs-Knorr glycosylation as key steps. The tyrosinase inhibitory activity of 7–12 increased with the length of the alkyl spacer between resorcinol and glucose. The 50% inhibitory concentration (IC₅₀) of tetradecyl derivative 12 was 0.39 μM, making it the most potent of the compounds synthesized. The IC₅₀ of 8 (3.62 μM) with a propyl spacer was ca 10 times that of 7 (35.9 μM) with an ethyl spacer. This significant activity difference suggests that an interaction between resorcinol alkyl glucoside and tyrosinase may increase remarkably if the length of the alkyl spacer exceeds C₃.

间苯二酚烷基葡糖苷7 - 12被开发基于rhododendrin的结构新颖的酪氨酸酶抑制剂。这些是使用Wientig或Horner-Wadsworth-Emmons反应，以Koenigs-Knorr糖基化为关键步骤，由2,4-二苄氧基苯甲醛合成的。随着间苯二酚和葡萄糖之间的烷基间隔物的长度增加，酪氨酸酶的抑制活性为7 – 12。十四烷基衍生物12的50％抑制浓度（IC ₅₀）为0.39μM，使其成为合成化合物中最有效的。具有丙基间隔基的IC ₅₀为8（3.62μM），约为7的10倍（35.9μM）和乙基间隔基。这种显着的活性差异表明，如果烷基间隔基的长度超过C ₃，间苯二酚烷基葡糖苷和酪氨酸酶之间的相互作用可能会显着增加。