Abstract Distillation precipitation polymerization (DPP) of acrylic acid were studied in the presence of two different crosslinkers including N,N′‑methylenebis(acrylamide) (MBA) and ethylene glycol dimethacrylate (EGDAMA). After morphological study of the resultant particles, the best morphological sample was selected as seed for seeded emulsion polymerization (SEP). Composite particles were fabricated by SEP of 2‑(dimethylamino)ethyl methacrylate (DMAEMA) and MBA as crosslinked. Patchy particles, polyhedral core-shell particles, cauliflower-like particles, core-shell particles with porous shell, dumbbell-like particles and core-shell particles were synthesized by different strategies. The size, structure and surface morphology of synthesized particles were characterized using DLS and FE-SEM techniques. Morphology development and mechanism of shell formation such as nucleation and growth of lobes on seed particles were investigated. Finally, well-defined morphologies have been used as doxorubicin hydrochloride (DOX) anti-cancer drug carriers and DOX release kinetics has been discussed by different mathematical models.

中文翻译：

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研究聚（丙烯酸）/聚（2-（二甲氨基）乙基甲基丙烯酸乙酯）复合颗粒的 Janus 形态发展：DOX 释放的实验研究和数学建模

摘要 研究了在 N,N'-亚甲基双（丙烯酰胺）（MBA）和乙二醇二甲基丙烯酸酯（EGDAMA）两种不同交联剂存在下丙烯酸的蒸馏沉淀聚合（DPP）。在对所得颗粒进行形态研究后，选择最佳形态样品作为种子乳液聚合 (SEP) 的种子。复合颗粒由甲基丙烯酸 2-（二甲氨基）乙酯 (DMAEMA) 和 MBA 交联的 SEP 制成。通过不同的策略合成了片状颗粒、多面体核壳颗粒、花椰菜状颗粒、多孔壳核壳颗粒、哑铃状颗粒和核壳颗粒。使用 DLS 和 FE-SEM 技术表征合成颗粒的尺寸、结构和表面形态。研究了壳形成的形态发展和机制，例如种子颗粒上裂片的成核和生长。最后，明确定义的形态已被用作盐酸多柔比星 (DOX) 抗癌药物载体，并且已通过不同的数学模型讨论了 DOX 释放动力学。