The interplay between the actin cytoskeleton and mitochondria has been implicated in cell and tissue homeostasis and physiological function. In this issue of Science Signaling, Nishimura et al. demonstrate that inhibiting the interaction of filamin A, an actin cytoskeleton regulator, with Drp1, a modulator of mitochondrial dynamics, attenuates mitochondrial hyperfission and cardiomyocyte senescence after myocardial infarction.

中文翻译：

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细胞骨架锚连接缺血性线粒体裂变与心肌衰老

肌动蛋白细胞骨架和线粒体之间的相互作用已被认为与细胞和组织的动态平衡和生理功能有关。在本期《科学信号》中，Nishimura等人。证明抑制纤维蛋白A（肌动蛋白细胞骨架调节剂）与线粒体动力学调节剂Drp1的相互作用，可减轻心肌梗塞后线粒体超裂变和心肌细胞衰老。