Abstract The electrochemical behavior of flutamide was investigated using a carbon paste electrode (CPE) modified by CuO nanoparticles/graphene oxide/polyaniline (CuO/GO/PANI) nanocomposite. Square wave and differential pulse voltammetry were studied in different concentrations of flutamide. Square wave voltammetry which is a rapid and sensitive method for reversible systems was used to determine flutamide. Based on the studies carried out by the present method, the electrode has an excellent electrochemical activity to the flutamide oxidation. Under the optimized experimental conditions, the sensor showed excellent linearity from 0.050 to 200.0 nM with a detection limit of 14.0 pM; the best values obtained already for flutamide. The modified electrode was applied for the determination of flutamide in human urine and pharmaceutical samples with satisfy results.

中文翻译：

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CuO/GO/PANI纳米复合材料修饰碳糊电极方波伏安法测定抗癌药物氟他胺

摘要 使用由氧化铜纳米颗粒/氧化石墨烯/聚苯胺 (CuO/GO/PANI) 纳米复合材料修饰的碳糊电极 (CPE) 研究了氟他胺的电化学行为。在不同浓度的氟他胺中研究了方波和差分脉冲伏安法。方波伏安法是一种快速、灵敏的可逆系统方法，用于测定氟他胺。基于本方法进行的研究，该电极对氟他胺氧化具有优异的电化学活性。在优化的实验条件下，传感器在 0.050 至 200.0 nM 范围内表现出优异的线性，检测限为 14.0 pM；氟他胺已经获得的最佳值。