In this work, a systematic methodology to obtain third-generation bioceramics within the Ca₂SiO₄-Ca₃(PO₄)-NaCaPO₄ternary system is proposed. The synthesis of Silicocarnotite (Ca_5-x(PO₄)_2+x(SiO₄)_1-x; x ≤ 0.3) (SC) and Nagelschmidtite (Ca_7-xNa_x(PO₄)_2+x(SiO₄)_2-x; x ≤ 2) (Nagel) single phases, from mixtures of bovine-derived HAp (BHAp) and 45S5-bioactive glass (BG) as precursors was developed using design of experiments (DoE). A combination of milling and sintering processing parameters was established by statistical analysis to optimize the microstructural and mechanical properties of BHAp/BG ceramics. The optimized sintering temperature obtained with simultaneous responses was 1220 °C. Variations in BHAp/BG ratios lead to isothermal phase transformation to single crystalline phases, where 85/15 and 70/30 vol:vol ratios transformed to SC and Nagel, respectively. Finally, the proposed methodology allows a feasible composition control depending only of BHAp/BG ratio to obtain non-stoichiometric SC and Nagel phases with potential applications in bone repair.

在这项工作中，提出了一种在Ca ₂ SiO ₄ -Ca ₃（PO ₄）-NaCaPO ₄三元体系中获得第三代生物陶瓷的系统方法。硅碳钙石（Ca _5-x（PO ₄）_{2 + x}（SiO ₄）_1-x ; x≤0.3）（SC）和钠长石（Ca _7-x Na _x（PO ₄）_{2 + x}（SiO ₄）的_合成）_2-x; 使用实验设计（DoE），开发了以牛源HAp（BHAp）和45S5-生物活性玻璃（BG）的混合物为前体的x≤2）（Nagel）单相。通过统计分析建立了铣削和烧结工艺参数的组合，以优化BHAp / BG陶瓷的微观结构和力学性能。同时获得的最佳烧结温度为1220°C。BHAp / BG比值的变化会导致等温相转变为单晶相，其中85/15和70/30的体积：体积比分别转化为SC和Nagel。最后，所提出的方法允许仅依靠BHAp / BG比率进行可行的成分控制，以获得非化学计量的SC和Nagel相，并在骨修复中具有潜在的应用。