Depression is more common in obese than non-obese individuals, especially in women, but the causal relationship between obesity and depression is complex and uncertain. Previous studies have used genetic variants associated with BMI to provide evidence that higher body mass index (BMI) causes depression, but have not tested whether this relationship is driven by the metabolic consequences of BMI nor for differences between men and women.

中文翻译：

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利用遗传学了解较高的 BMI 对抑郁症的因果影响

抑郁症在肥胖者中比非肥胖者更常见，尤其是在女性中，但肥胖与抑郁症之间的因果关系复杂且不确定。先前的研究已经使用与BMI相关的遗传变异来提供证据，证明较高的体重指数（BMI）会导致抑郁症，但尚未测试这种关系是否是由BMI的代谢后果驱动的，也没有测试男女之间的差异。