Synchronous sensing of three conserved sequences of Zika virus using a DNAs@MOF hybrid: experimental and molecular simulation studies†,Inorganic Chemistry Frontiers

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Synchronous sensing of three conserved sequences of Zika virus using a DNAs@MOF hybrid: experimental and molecular simulation studies†
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2018-11-13 00:00:00 , DOI: 10.1039/c8qi01031e
Bao-Ping Xie _{1,

2,

3,

4,

5} , Gui-Hua Qiu _{1,

2,

3,

4,

5} , Bin Sun _{1,

2,

3,

4,

5} , Zi-Feng Yang _{5,

6,

7,

8,

9} , Wen-Hua Zhang _{5,

10,

11,

12,

13} , Jin-Xiang Chen _{1,

2,

3,

4,

5} , Zhi-Hong Jiang _{5,

6,

7,

8,

9}

Affiliation

A metal–organic framework of Cu(II) supported by a zwitterionic pyridinium dicarboxylate and 4,4′-bipyridine mixed ligands was prepared and impregnated with three dye-labeled DNA sequences with fixed wavelength differences. This hybrid material formed is capable of the synchronous detection of three conserved Zika virus RNA sequences with high sensitivity and selectivity, and low detection limits of 0.56 ± 0.02, 0.16 ± 0.04, and 0.19 ± 0.05 nM, without any cross-reactions, as confirmed by both experimental and molecular simulation studies.

中文翻译：

使用DNAs @ MOF杂合体同步感测寨卡病毒的三个保守序列：实验和分子模拟研究†

用两性离子吡啶鎓二羧酸盐和4,4'-联吡啶混合的配体支撑的Cu（II）的金属有机框架被制备并浸渍了三个染料标记的具有固定波长差异的DNA序列。形成的这种杂化材料能够以高灵敏度和选择性，0.56±0.02、0.16±0.04和0.19±0.05 nM的低检测限同步检测三个保守的寨卡病毒RNA序列，已证实没有交叉反应通过实验和分子模拟研究。

更新日期：2018-11-13

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