Abstract The synthesis of multi-stimuli responsive peptide-poly(ethylene glycol) ABA-type conjugates is reported. The β-sheet encoded intramolecular folding and intermolecular self-assembly into 1D nanorods is based on a phenylalanine(F)-methionine(M)-histidine(H) FMHMHF hexapeptide sequence, and the supramolecular nanorods are stabilised by a shielding corona of hydrophilic PEG polymers. Interstrand crosslinking leads to the formation of physical networks and hydrogels at physiological pH and at room temperature. The thioether functional groups integrate oxidation responsive properties in the supramolecular polymer assemblies. We show that the glucose fuelled and glucose oxidase catalysed production of the reactive oxygen species (ROS) leads to transiently stable supramolecular hydrogels that operate in a fully autonomous reaction set-up, with a tuneable gelation life-times of 1–12 h. ROS play an important role in signalling cascades and inflammation processes. We are therefore particularly interested in further developing our strategy for the design of biomaterials for applications in redox microenvironments.

中文翻译：

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使用 ROS 响应的遥爪肽-聚合物偶联物调节超分子水凝胶的使用寿命

摘要 报道了多刺激响应肽-聚（乙二醇）ABA 型偶联物的合成。β-折叠编码的分子内折叠和分子间自组装成一维纳米棒基于苯丙氨酸（F）-甲硫氨酸（M）-组氨酸（H）FMHMHF 六肽序列，超分子纳米棒通过亲水性 PEG 的屏蔽电晕稳定聚合物。链间交联导致在生理 pH 值和室温下形成物理网络和水凝胶。硫醚官能团在超分子聚合物组装体中整合了氧化响应特性。我们表明，以葡萄糖为燃料和葡萄糖氧化酶催化的活性氧 (ROS) 产生导致在完全自主的反应装置中运行的瞬时稳定的超分子水凝胶，可调节的凝胶寿命为 1-12 小时。ROS 在信号级联和炎症过程中发挥重要作用。因此，我们特别有兴趣进一步发展我们设计用于氧化还原微环境的生物材料的策略。