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Cinnamaldehyde-Based Poly(ester-thioacetal) To Generate Reactive Oxygen Species for Fabricating Reactive Oxygen Species-Responsive Nanoparticles
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-11-12 00:00:00 , DOI: 10.1021/acs.biomac.8b01423 Long Xu 1 , Mingying Zhao 2 , Hai Zhang 3 , Wenxia Gao 4 , Zhaoyuan Guo 3 , Xuequan Zhang 2 , Jianfeng Zhang 1 , Jun Cao 3 , Yuji Pu 3 , Bin He 3
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-11-12 00:00:00 , DOI: 10.1021/acs.biomac.8b01423 Long Xu 1 , Mingying Zhao 2 , Hai Zhang 3 , Wenxia Gao 4 , Zhaoyuan Guo 3 , Xuequan Zhang 2 , Jianfeng Zhang 1 , Jun Cao 3 , Yuji Pu 3 , Bin He 3
Affiliation
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Due to the high oxidative stress of the tumor microenvironment, more and more researchers have been devoted to reactive oxygen species (ROS)-responsive nanodrug delivery systems for anticancer therapy. Herein, a ROS-responsive moiety, thioacetal, was synthesized, and cinnamaldehyde (CA) was introduced in the polymer chain to trigger the generation of ROS to expect the enhancement of the ROS-responsive effect. The poly(ester-thioacetal) mPEG2k-b-(NTA-HD)12 polymer, its self-assembled micelles, and the ROS-responsive behavior were characterized by 1H NMR and DLS. The anticancer drug doxorubicin (DOX) was adopted to prepare DOX-loaded poly(ester-thioacetal) micelles. The intracellular ROS detection indicated that the mPEG2k-b-(NTA-HD)12 polymer could degrade via the high concentration of ROS in cancer cells, and the released CA stimulated mitochondria to regenerate additional ROS. The flow cytometry results indicated that the ROS-responsive polymeric micelles showed faster cellular uptake compared to the control mPEG2k-b-PCL5k micelles. The ROS responsive DOX/mPEG2k-b-(NTA-HD)12 micelles exhibited much better anticancer efficiency on both 4T1 and HeLa cancer cells than DOX/mPEG2k-b-PCL5k micelles.
中文翻译：
基于肉桂醛的聚（酯-硫缩醛）生成用于制备反应性氧物种响应性纳米粒子的反应性氧物种。
由于肿瘤微环境的高氧化应激，越来越多的研究人员致力于活性氧（ROS）反应型纳米药物递送系统的抗癌治疗。在此，合成了ROS响应部分硫缩醛，并且在聚合物链中引入了肉桂醛（CA）以触发ROS的产生，以期望ROS响应效果的增强。的聚（酯-硫缩醛）mPEG2k - b -（NTA-HD）12由聚合物，其自组装胶束，和ROS-响应行为进行了表征1 H NMR和DLS。采用抗癌药阿霉素（DOX）制备载有DOX的聚（酯-硫缩醛）胶束。细胞内ROS检测表明mPEG2k- b -（NTA-HD）12聚合物可以通过在癌细胞中高浓度的ROS的降解，并释放CA刺激线粒体再生附加ROS。流式细胞仪结果表明，与对照mPEG2k - b - PCL5k胶束相比，ROS反应性聚合物胶束显示出更快的细胞摄取。所述ROS响应DOX / mPEG2k - b -（NTA-HD）12个胶束显示出好得多的在两个4T1细胞和HeLa癌细胞比DOX / mPEG2k抗癌效率- b - PCL5k胶束。
更新日期：2018-11-12
中文翻译：
基于肉桂醛的聚（酯-硫缩醛）生成用于制备反应性氧物种响应性纳米粒子的反应性氧物种。
由于肿瘤微环境的高氧化应激，越来越多的研究人员致力于活性氧（ROS）反应型纳米药物递送系统的抗癌治疗。在此，合成了ROS响应部分硫缩醛，并且在聚合物链中引入了肉桂醛（CA）以触发ROS的产生，以期望ROS响应效果的增强。的聚（酯-硫缩醛）mPEG2k - b -（NTA-HD）12由聚合物，其自组装胶束，和ROS-响应行为进行了表征1 H NMR和DLS。采用抗癌药阿霉素（DOX）制备载有DOX的聚（酯-硫缩醛）胶束。细胞内ROS检测表明mPEG2k- b -（NTA-HD）12聚合物可以通过在癌细胞中高浓度的ROS的降解，并释放CA刺激线粒体再生附加ROS。流式细胞仪结果表明，与对照mPEG2k - b - PCL5k胶束相比，ROS反应性聚合物胶束显示出更快的细胞摄取。所述ROS响应DOX / mPEG2k - b -（NTA-HD）12个胶束显示出好得多的在两个4T1细胞和HeLa癌细胞比DOX / mPEG2k抗癌效率- b - PCL5k胶束。
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