Medicago sativa L. is a forage legume plant widely distributed in all continents. Six new triterpenoid saponins, Medicagosides A-F (1–6) and five known ones (7–11) were isolated from M. sativa. Their structures were determined via HRESIMS, 1D and 2D NMR analysis. Biologically, all the isolates displayed neuroprotective activities against H₂O₂-induced damage in SH-SY5Y cells. Among them, compounds 1, 3–5 and 10 exhibited striking neuroprotective activities at 100 μM, restoring cell viability range from 79.66% to 89.03%, relative to 79.46% (100 μM) of Trolox used as the positive control.

苜蓿（Medicago sativa L.）是一种豆科植物，广泛分布于各大洲。六个新的三萜皂甙，Medicagosides AF（1 - 6）和五个已知的那些（7 - 11）从分离中号。苜蓿。通过HRESIMS，1D和2D NMR分析确定了它们的结构。从生物学上讲，所有分离株均对SH-SY5Y细胞中的H ₂ O ₂诱导的损伤表现出神经保护活性。其中，化合物1，3 - 5和10 在100μM时表现出惊人的神经保护活性，相对于Trolox用作阳性对照的79.46％（100μM），细胞活力恢复率为79.66％至89.03％。