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Neuroprotective effects of triterpenoid saponins from Medicago sativa L. against H2O2-induced oxidative stress in SH-SY5Y cells
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2018-11-13 , DOI: 10.1016/j.bioorg.2018.11.008
Xue-Gui Liu , Yu-Qiu Sun , Jun Bian , Ting Han , Dan-Dan Yue , Dan-Qi Li , Pin-Yi Gao

Medicago sativa L. is a forage legume plant widely distributed in all continents. Six new triterpenoid saponins, Medicagosides A-F (16) and five known ones (711) were isolated from M. sativa. Their structures were determined via HRESIMS, 1D and 2D NMR analysis. Biologically, all the isolates displayed neuroprotective activities against H2O2-induced damage in SH-SY5Y cells. Among them, compounds 1, 35 and 10 exhibited striking neuroprotective activities at 100 μM, restoring cell viability range from 79.66% to 89.03%, relative to 79.46% (100 μM) of Trolox used as the positive control.



中文翻译:

紫花苜蓿三萜皂苷对H 2 O 2诱导的SH-SY5Y细胞氧化应激的神经保护作用

苜蓿(Medicago sativa L.)是一种豆科植物,广泛分布于各大洲。六个新的三萜皂甙,Medicagosides AF(1 - 6)和五个已知的那些(7 - 11)从分离中号苜蓿。通过HRESIMS,1D和2D NMR分析确定了它们的结构。从生物学上讲,所有分离株均对SH-SY5Y细胞中的H 2 O 2诱导的损伤表现出神经保护活性。其中,化合物13 - 510 在100μM时表现出惊人的神经保护活性,相对于Trolox用作阳性对照的79.46%(100μM),细胞活力恢复率为79.66%至89.03%。

更新日期:2018-11-13
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