Closed-loop all-optical interrogation of neural circuits in vivo.,Nature Methods

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Closed-loop all-optical interrogation of neural circuits in vivo.
Nature Methods ( IF 36.1 ) Pub Date : 2018-11-12 , DOI: 10.1038/s41592-018-0183-z
Zihui Zhang _{1,

2} , Lloyd E Russell ₁ , Adam M Packer _{1,

3} , Oliver M Gauld ₁ , Michael Häusser ₁

Affiliation

Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity ‘on the fly’ during behavior.

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