Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.,Nature Medicine

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Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
Nature Medicine ( IF 58.7 ) Pub Date : 2018-11-12 , DOI: 10.1038/s41591-018-0238-9
Yinghong Wang ₁ , Diana H Wiesnoski ₂ , Beth A Helmink ₃ , Vancheswaran Gopalakrishnan ₃ , Kati Choi ₄ , Hebert L DuPont _{5,

6} , Zhi-Dong Jiang ₅ , Hamzah Abu-Sbeih ₁ , Christopher A Sanchez ₂ , Chia-Chi Chang ₂ , Edwin R Parra ₇ , Alejandro Francisco-Cruz ₇ , Gottumukkala S Raju ₁ , John R Stroehlein ₁ , Matthew T Campbell ₈ , Jianjun Gao ₈ , Sumit K Subudhi ₈ , Dipen M Maru ₉ , Jorge M Blando ₁₀ , Alexander J Lazar _{2,

9} , James P Allison ₁₀ , Padmanee Sharma _{8,

10} , Michael T Tetzlaff _{7,

9} , Jennifer A Wargo _{2,

3} , Robert R Jenq _{2,

11}

Affiliation

Department of Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
Center for Infectious Diseases, School of Public Health, The University of Texas, Houston, TX, USA.
Kelsey Research Foundation, Houston, TX, USA.
Department of Translational Molecular Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Pathology, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Immunology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.

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